Involvement of epithelial to mesenchymal transition in the development of pancreatic ductal adenocarcinoma

Kennichi Satoh, Shin Hamada, Tooru Shimosegawa

研究成果: Review article査読

32 被引用数 (Scopus)

抄録

Pancreatic ductal adenocarcinoma (PDAC) is an intractable disease as a result of its rapid dissemination and resistance to conventional chemotherapy and radiotherapy. Surgical resection is the only curative therapy, but most of the tumors are unresectable at the time of diagnosis. The molecular mechanisms underlying the biological aggressiveness of this tumor type remain to be clarified. Epithelial to mesenchymal transition (EMT) is a developmental process that leads the phenotype shift from an epithelial morphology to a motile, fibroblast-like morphology. Recent studies showed that EMT is involved in the invasion and metastasis of many types of carcinomas including PDAC. In addition, PDAC cells with the EMT phenotype also exhibit chemoresistance and the cancer stem cell property. Various factors such as cytokines, growth factors, or transcriptional factors were found to promote the EMT program in PDAC cells. In this review, we summarize the current knowledge about the EMT in PDAC cells, focusing on the involvement of this process and its regulatory molecules including microRNA during the development of PDAC cells.

本文言語English
ページ(範囲)140-146
ページ数7
ジャーナルJournal of gastroenterology
50
2
DOI
出版ステータスPublished - 2014 2月

ASJC Scopus subject areas

  • 消化器病学

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