Intrinsic Projections of Layer Vb Neurons to Layers Va, III, and II in the Lateral and Medial Entorhinal Cortex of the Rat

Shinya Ohara, Mariko Onodera, Øyvind W. Simonsen, Rintaro Yoshino, Hiroyuki Hioki, Toshio Iijima, Ken Ichiro Tsutsui, Menno P. Witter

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Layer V of the entorhinal cortex (EC) receives input from the hippocampus and originates main entorhinal outputs. The deep-sublayer Vb, immunopositive for the transcription factor Ctip2, is thought to be the main recipient of hippocampal projections, whereas the superficial-sublayer LVa, immunonegative for Ctip2, originates the main outputs of EC. This disrupts the proposed role of EC as mediating hippocampal-cortical interactions. With the use of specific (trans)synaptic tracing approaches, we report that, in medial entorhinal cortex, layer Vb neurons innervate neurons in layers Va, II, and III. A similar circuitry exists in the lateral entorhinal cortex. We conclude that EC-layer Vb neurons mediate two circuits in the hippocampus-memory system: (1) a hippocampal output circuit to telencephalic areas by projecting to layer Va and (2) a feedback projection, sending information back to the EC-hippocampal loop via neurons in layers II and III.

本文言語English
ページ(範囲)107-116
ページ数10
ジャーナルCell Reports
24
1
DOI
出版ステータスPublished - 2018 7 3

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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