Intrarenal angiotensin converting enzyme inhibition in spontaneously hypertensive rats

Hajime Aihara, Hiromi Ogawa, Akira Kasuya, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Susumu Satoh

研究成果: Article査読

8 被引用数 (Scopus)

抄録

We examined the hypotensive effect of enalapril in relation to the local renin-angiotensin system of the kidney in spontaneously hypertensive rats (SHR). Oral administration of enalapril for 7 days decreased mean arterial blood pressure and renal tissue angiotensin II concentration without affecting plasma angiotensin II concentration in SHR. The enalapril treatment did not affect maximum binding of angiotensin II to renal tubules and glomeruli in SHR. In normotensive Wistar-Kyoto rats, no significant changes in mean arterial blood pressure, renal and plasma angiotensin levels were observed with enalapril treatment. Direct infusion of enalapril into the renal medullary interstitium decreased mean arterial blood pressure in association with the reduction of renal tissue angiotensin II concentration without changes in plasma angiotensin II concentration in SHR. These observations suggest that the inhibition of angiotensin conversion in the kidney is important for the hypotensive action of enalapril.

本文言語English
ページ(範囲)35-40
ページ数6
ジャーナルEuropean Journal of Pharmacology
373
1
DOI
出版ステータスPublished - 1999 5 28

ASJC Scopus subject areas

  • 薬理学

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