抄録
A novel catalytic cyclization reaction of alkynyl α-ketoanilide was developed by utilizing the [1,2]-phospha-Brook rearrangement. This reaction involves the generation of an amide enolate via the umpolung process, that is the addition of dialkyl phosphite to a keto moiety followed by the [1,2]-phospha-Brook rearrangement, and the subsequent intramolecular addition of the enolate to an alkyne to afford 3,4-dihydro-2-quinolone derivatives. Under high-temperature reaction conditions, further rearrangement of the allylic phosphate moiety occurs to provide 2-quinolone derivatives.
本文言語 | English |
---|---|
ページ(範囲) | 3528-3531 |
ページ数 | 4 |
ジャーナル | Organic letters |
巻 | 16 |
号 | 13 |
DOI | |
出版ステータス | Published - 2014 7月 3 |
ASJC Scopus subject areas
- 生化学
- 物理化学および理論化学
- 有機化学