Intracrine mechanism of estrogen synthesis in breast cancer

Takashi Suzuki, Takuya Moriya, Takanori Ishida, Noriaki Ohuchi, Hironobu Sasano

研究成果: Article査読

31 被引用数 (Scopus)

抄録

It has been demonstrated that biologically active estrogens are locally produced from circulating inactive steroids in an intracrine mechanism in the breast carcinoma. The in situ production of estrogens is considered to play an important role in the proliferation of breast cancer cells, especially in the postmenopausal women. Therefore, the total blockade of this pathway may lead to an improvement in the prognosis in breast cancer patients due to the inhibition of estrogenic actions. In this review, we describe the recent studies of enzymes related to intracrine mechanism of estrogen synthesis, including aromatase, steroid sulfatase (STS), and 17β-hydroxysteroid dehydrogenase, in human breast carcinoma tissues, and discuss the biological significance of local production of estrogens in human breast cancer.

本文言語English
ページ(範囲)460-462
ページ数3
ジャーナルBiomedicine and Pharmacotherapy
57
10
DOI
出版ステータスPublished - 2003 12

ASJC Scopus subject areas

  • 薬理学

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