TY - JOUR
T1 - Intraarterial chemotherapy for metastatic renal cell carcinomas
T2 - Combination with MDR-overcoming agents
AU - Kakehi, Y.
AU - Yoshida, O.
AU - Segawa, T.
AU - Kanematsu, A.
AU - Hiura, M.
AU - Shichiri, Y.
AU - Arai, Y.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - We analyzed the sensitizing activity of five agents, which have been assumed to be MDR-overcoming drugs, in two human renal cell carcinoma cell lines expressing the MDR1 gene at high levels. In addition, we studied the sensitizing activity of cepharanthin, an MDR-overcoming agents, to vinblastine, adriamycin, epirubicin, cisplatin, mitomycin C and etoposide. Based on the results, we treated 6 patients with metastatic renal cell carcinomas (4: bones, 2: contralateral kidneys) by intraarterial injection of vinblastine and adriamycin (or epirubicin) in combination with cepharanthin. Two of the 4 bone metastasis cases responded markedly to the treatment. Renal tubular impairment was observed in one patient who was treated for the contralateral kidney metastasis.
AB - We analyzed the sensitizing activity of five agents, which have been assumed to be MDR-overcoming drugs, in two human renal cell carcinoma cell lines expressing the MDR1 gene at high levels. In addition, we studied the sensitizing activity of cepharanthin, an MDR-overcoming agents, to vinblastine, adriamycin, epirubicin, cisplatin, mitomycin C and etoposide. Based on the results, we treated 6 patients with metastatic renal cell carcinomas (4: bones, 2: contralateral kidneys) by intraarterial injection of vinblastine and adriamycin (or epirubicin) in combination with cepharanthin. Two of the 4 bone metastasis cases responded markedly to the treatment. Renal tubular impairment was observed in one patient who was treated for the contralateral kidney metastasis.
KW - MDR-overcoming agents
KW - intraarterial chemotherapy
KW - metastasis
KW - renal cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=0028061740&partnerID=8YFLogxK
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M3 - Article
C2 - 7992710
AN - SCOPUS:0028061740
VL - 40
SP - 925
EP - 929
JO - Acta Urologica Japonica
JF - Acta Urologica Japonica
SN - 0018-1994
IS - 10
ER -