Intraarterial chemotherapy for metastatic renal cell carcinomas: Combination with MDR-overcoming agents

Y. Kakehi, O. Yoshida, T. Segawa, A. Kanematsu, M. Hiura, Y. Shichiri, Y. Arai

研究成果: Article査読

6 被引用数 (Scopus)

抄録

We analyzed the sensitizing activity of five agents, which have been assumed to be MDR-overcoming drugs, in two human renal cell carcinoma cell lines expressing the MDR1 gene at high levels. In addition, we studied the sensitizing activity of cepharanthin, an MDR-overcoming agents, to vinblastine, adriamycin, epirubicin, cisplatin, mitomycin C and etoposide. Based on the results, we treated 6 patients with metastatic renal cell carcinomas (4: bones, 2: contralateral kidneys) by intraarterial injection of vinblastine and adriamycin (or epirubicin) in combination with cepharanthin. Two of the 4 bone metastasis cases responded markedly to the treatment. Renal tubular impairment was observed in one patient who was treated for the contralateral kidney metastasis.

本文言語English
ページ(範囲)925-929
ページ数5
ジャーナルActa Urologica Japonica
40
10
出版ステータスPublished - 1994 1月 1

ASJC Scopus subject areas

  • 泌尿器学

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