Intestinal Absorption and Tissue Distribution of Aza-Sugars from Mulberry Leaves and Evaluation of Their Transport by Sugar Transporters

Soo Takasu, Isabella S. Parida, Junya Ito, Yoshihiro Kojima, Takahiro Eitsuka, Toshiyuki Kimura, Kiyotaka Nakagawa

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Mulberry leaves are rich in aza-sugars, particularly 1-deoxynojirimycin (DNJ), fagomine, and 2-O-α-d-galactopyranosyl-1-deoxynojirimycin (GAL-DNJ), which have antidiabetes and antiobesity properties. To help us understand the mechanisms of action of aza-sugars, pharmacokinetic studies are necessary. Therefore, in this study, we evaluated and compared the absorption and organ distribution of these aza-sugars in rats. Following oral intake, DNJ exhibited the highest plasma concentration followed by fagomine and GAL-DNJ. Meanwhile, similar amounts of DNJ and fagomine were present in organs, while GAL-DNJ was hardly detected, suggesting the diversity in absorption and distribution characteristics of these aza-sugars. We then investigated the role of the sodium-glucose cotransporter and the glucose transporter (GLUT) in the transport of aza-sugars and found that both are involved in DNJ transport, while transport of fagomine is solely facilitated by the GLUT. These findings provide insight into the bioavailability and bioactive mechanisms of these aza-sugars.

本文言語English
ページ(範囲)6656-6663
ページ数8
ジャーナルJournal of Agricultural and Food Chemistry
68
24
DOI
出版ステータスPublished - 2020 6 17

ASJC Scopus subject areas

  • 化学 (全般)
  • 農業および生物科学(全般)

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