### 抜粋

Background: Previous studies have shown various risk factors for the initial and/or the second operation for Crohn's disease (CD). However, limited data are available with regard to the risk factors for a third operation. We aimed to clarify the risk factors for a third operation for CD. Methods: A total of 200 CD patients who underwent a second intestinal surgery at 13 institutions were examined. We performed univariate and multivariate analyses to examine the influence of independent variables on the cumulative rate of needing a third operation. Results: A total of 95 patients underwent a third operation. The overall 5-year and 10-year cumulative rates for the third operation were 42.2% and 71.0%, respectively. In univariate analysis, the interval between the initial and the second operation (P = 0.0069), postoperative administration of infliximab (P = 0.0030), and the anatomical site of the disease (P = 0.0132) were significant risk factors for the third operation. In multivariate analysis, the interval between the initial and the second operation (P = 0.0287) and postoperative administration of infliximab (P = 0.0297) remained significant risk factors for the third operation. The cumulative 5-year third operation rate was significantly higher in patients with an interval of less than 5 years between the first and second operations than for those with an interval of 5 years or more (47.8% versus 35.2%, P = 0.0232). Conclusions: An interval of less than 5 years between the first and the second operations is a significant risk factor for a third operation in patients with CD.

元の言語 | English |
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ページ（範囲） | 17-24 |

ページ数 | 8 |

ジャーナル | Inflammatory Bowel Diseases |

巻 | 18 |

発行部数 | 1 |

DOI | |

出版物ステータス | Published - 2012 1 |

### ASJC Scopus subject areas

- Immunology and Allergy
- Gastroenterology

## フィンガープリント Interval of less than 5 years between the first and second operation is a risk factor for a third operation for Crohn's disease' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

## これを引用

*Inflammatory Bowel Diseases*,

*18*(1), 17-24. https://doi.org/10.1002/ibd.21671