Interleukin-2 (IL-2) induces erythroid differentiation and tyrosine phosphorylation in ELM-I-1 cells transfected with a human IL-2 receptor β chain cDNA

Kazunori Imada, Mitsuru Tsudo, Tai ichi Kodaka, Katsuhiko Itoh, Nobuyoshi Arima, Toshio Hattori, Minoru Okuma, Takashi Uchiyama

研究成果: Article査読

2 被引用数 (Scopus)

抄録

The molecular mechanism of erythroid differentiation has been still ill-defined. In this study, we introduced a human interleukin-2 receptor (IL-2R) β chain cDNA into ELM-I-1 cells which differentiated into hemoglobin-positive cells in the presence of erythropoietin (Epo), and established the transformant which expressed IL-2R β chain. In this transformant, we revealed that IL-2 induced erythroid differentiation and the same pattern of tyrosine phosphorylation as Epo. These data suggest that tyrosine phosphorylation is involved in signal transduction pathway of erythroid differentiation. It is also implicated that the Epo and IL-2 receptor system share a common signal transduction pathway.

本文言語English
ページ(範囲)352-357
ページ数6
ジャーナルBiochemical and biophysical research communications
188
1
DOI
出版ステータスPublished - 1992 10月 15
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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