Interleukin-2 (IL-2) induces erythroid differentiation and tyrosine phosphorylation in ELM-I-1 cells transfected with a human IL-2 receptor β chain cDNA

Kazunori Imada, Mitsuru Tsudo, Tai ichi Kodaka, Katsuhiko Itoh, Nobuyoshi Arima, Toshio Hattori, Minoru Okuma, Takashi Uchiyama

研究成果: Article

2 引用 (Scopus)

抜粋

The molecular mechanism of erythroid differentiation has been still ill-defined. In this study, we introduced a human interleukin-2 receptor (IL-2R) β chain cDNA into ELM-I-1 cells which differentiated into hemoglobin-positive cells in the presence of erythropoietin (Epo), and established the transformant which expressed IL-2R β chain. In this transformant, we revealed that IL-2 induced erythroid differentiation and the same pattern of tyrosine phosphorylation as Epo. These data suggest that tyrosine phosphorylation is involved in signal transduction pathway of erythroid differentiation. It is also implicated that the Epo and IL-2 receptor system share a common signal transduction pathway.

元の言語English
ページ(範囲)352-357
ページ数6
ジャーナルBiochemical and biophysical research communications
188
発行部数1
DOI
出版物ステータスPublished - 1992 10 15

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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