Intercellular adhesion molecule 1-dependent activation of interleukin 8 expression in Candida albicans-infected human gingival epithelial cells

Hiroshi Egusa, Hiroki Nikawa, Seicho Makihira, Anahid Jewett, Hirofumi Yatani, Taizo Hamada

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Increased induction of interleukin 8 (IL-8) and intercellular adhesion molecule 1 (ICAM-1) by oral epithelial cells may play a role in the host defense mechanism in oropharyngeal candidiasis; however, little is known about the expression feature of these molecules on human gingival epithelial cells (HGECs) during Candida albicans infection. In this report we present evidence that neutralization with antibody against ICAM-1 inhibited both the adherence of C. albicans to HGECs and the Candida-induced production of IL-8, suggesting a role for ICAM-1 in recognition and signaling in HGECs to express IL-8 upon infection with C. albicans.

本文言語English
ページ(範囲)622-626
ページ数5
ジャーナルInfection and immunity
73
1
DOI
出版ステータスPublished - 2005 1

ASJC Scopus subject areas

  • 寄生虫科
  • 微生物学
  • 免疫学
  • 感染症

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