Interaction between quaternary ammonium ions and dipeptides: Positive anion allosteric effect

Kazuaki Ito, Kayo Nagase, Naoya Morohashi, Yoshihiro Ohba

研究成果: Article査読

17 被引用数 (Scopus)

抄録

The binding properties of dipeptides possessing aromatic residues towards quaternary ammonium ions have been investigated by 1H-NMR spectroscopy. The intermolecular hydrogen bonding between exchangeable protons (OH and NH) of aromatic residues of dipeptides and the counter anion of ammonium ion is the primary force. After the formation of the intermolecular hydrogen bonding, two aromatic residues of dipeptides can provide π-base cavity to interact with the quaternary ammonium moiety.

本文言語English
ページ(範囲)90-94
ページ数5
ジャーナルChemical and Pharmaceutical Bulletin
53
1
DOI
出版ステータスPublished - 2005 1

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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