Interaction between leptospiral lipopolysaccharide and toll-like receptor 2 in pig fibroblast cell line, and inhibitory effect of antibody against leptospiral lipopolysaccharide on interaction

Yijie Guo, Tomokazu Fukuda, Shuichi Nakamura, Lanlan Bai, Jun Xu, Kengo Kuroda, Rintaro Tomioka, Hiroshi Yoneyama, Emiko Isogai

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Leptospiral lipopolysaccharide (L-LPS) has shown potency in activating toll-like receptor 2 (TLR2) in pig fibroblasts (PEFs-NCC1), and causes the expression of proinflammatory cytokines. However, the stimulation by L-LPS was weak eliciting the function of TLR2 sufficiently in pig innate immunity responses during Leptospira infection. In this study, the immune response of pig embryonic fibroblast cell line (PEFs-SV40) was investigated and was found to be the high immune response, thus TLR2 is the predominate receptor of L-LPS in pig cells. Further, we found a strategy using the antibody against L-LPS, to prevent L-LPS interaction with TLR2 in pig cells which could impact on immune activation.

本文言語English
ページ(範囲)273-279
ページ数7
ジャーナルAsian-Australasian Journal of Animal Sciences
28
2
DOI
出版ステータスPublished - 2015 2 1

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Engineering(all)

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