Intensity-Modulated Radiotherapy Triggers Onset of Bullous Pemphigoid in a Patient with Advanced Melanoma Treated with Nivolumab

Kayo Tanita, Taku Fujimura, Yumi Kambayashi, Akira Tsukada, Yota Sato, Akira Hashimoto, Setsuya Aiba

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Since the efficacy of ipilimumab on nivolumab-resistant advanced melanoma is extremely low, additional supportive therapy for anti-PD-1 antibody therapy-resistant advanced melanoma is needed. Although several supportive therapies that enhance the antitumor immune response of anti-PD-1 antibodies have already been reported, unexpected immune-related adverse events were detected at the same time. In this report, we describe a patient with advanced melanoma treated with nivolumab followed by intensity-modulated radiotherapy, which might have triggered bullous pemphigoid (BP). Although several cases of BP developing in anti-PD-1 antibody-treated patients have already been reported, in this report, we shed light on the possible pathogenesis of BP developing in a patient treated with nivolumab through M2 macrophages.

本文言語English
ページ(範囲)114-118
ページ数5
ジャーナルCase Reports in Oncology
11
1
DOI
出版ステータスPublished - 2018 1 19

ASJC Scopus subject areas

  • 腫瘍学

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