Insulin-releasing effect of quinaldic acid and its relatives on isolated Langerhans islets

Hiroshi Okamoto, Susumu Miyamoto, Hiroshi Mabuchi, Yoshimasa Yoneyama, Ryoyu Takeda

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Quinaldic acid and 8-hydroxyquinaldic acid, end-metabolites of kynurenine (1,2), were shown to cause release of insulin from isolated Langerhans islets of rats. In this respect, both kynurenic acid and xanthurenic acid were found to be somewhat less active than quinaldic acid, but L-kynurenine, 3-hydroxyl-L-kynurenine, quinolinic acid and L-tryptophan did not cause the insulin release. Possible correlation between disorder in tryptophan metabolisms directed toward the excessive formation of quinaldic acid and 8-hydroxyquinaldic acid and pathogenesis of diabetic state was discussed.

本文言語English
ページ(範囲)1297-1303
ページ数7
ジャーナルBiochemical and biophysical research communications
53
4
DOI
出版ステータスPublished - 1973 8 21
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「Insulin-releasing effect of quinaldic acid and its relatives on isolated Langerhans islets」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル