Insulin edema in diabetes mellitus associated with the 3243 mitochondrial tRNA Leu(UUR) mutation; Case reports

Yoshihiko Suzuki, Hiroko Kadowaki, Matsuo Taniyama, Takashi Kadowaki, Hideki Katagiri, Yoshitomo Oka, Yoshihito Atsumi, Kazuhiro Hosokawa, Yasushi Tanaka, Takayuki Asahina, Yukihiko Momiyama, Kempei Matsuoka

研究成果: Article査読

26 被引用数 (Scopus)


We encountered a patient with diabetes mellitus due to the 3243 mitochondrial tRNA mutation(DM-Mt3243), who developed insulin edema and hepatic dysfunction after starting insulin. Such a rare phenomenon was unlikely to be a fortuitous coincidence in mitochondrial diabetes, as none in 197 non-mutant NIDDM patients had same episode. Moreover, similar leg edema was noticed in another DM-Mt3243 patient, and other two DM-Mt3243 patients had leg edema which responded to coenzyme Q10. These observations suggest further a role of mitochondrial function on leg edema. The mechanism of his insulin edema may involve vasomotor changes induced by the rapidly glycemic control, because our case of insulin edema had a prominent increase of strong succinate dehydrogenase reactive vessels. Alternatively, myocardial dysfunction might have produced leg edema and hepatic dysfunction, because he had subclinical myocardial dysfunction, judged by imaging with β-methyl-p-( 123 I)- iodophenyl-pentadecanoic acid. The third explanation is that a rapid improvement of glycemic control might have induced hepatic reoxygenation and the production of reactive oxygen species in the liver that contributed to cell damage. Thus, although we cannot draw definite conclusion, our experiences here suggest that mitochondrial dysfunction is important in the etiology of insulin edema.

ジャーナルDiabetes Research and Clinical Practice
出版ステータスPublished - 1995 1 1

ASJC Scopus subject areas

  • 内科学
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学


「Insulin edema in diabetes mellitus associated with the 3243 mitochondrial tRNA <sup>Leu(UUR)</sup> mutation; Case reports」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。