Injectable polymeric nanosheets for subretinal cell delivery

研究成果: Conference contribution

抄録

Age-related macular degeneration (AMD) is one of the major ophthalmic diseases that cause visual impairment and blindness. Although transplantation of autologous peripheral cells has been attempted by injecting cell suspensions, limited visual improvement resulted due to the low viability of the injected cells in the subretinal tissue. We developed micropatterned polymeric nanosheets toward local delivery of retinal pigment epithelial (RPE) cells. The micropatterned nanosheet directed growth and morphogenesis of the RPE cells, and allowed for the injection of an engineered RPE monolayer through syringe needles flexibly into the subretinal space of rat eyes. Such an ultra-thin flexible carrier has the promise of a minimally invasive delivery of organized cellular structures into narrow tissue spaces.

本文言語English
ホスト出版物のタイトル16th International Conference on Nanotechnology - IEEE NANO 2016
出版社Institute of Electrical and Electronics Engineers Inc.
ページ267-269
ページ数3
ISBN(電子版)9781509039142
DOI
出版ステータスPublished - 2016 11 21
イベント16th IEEE International Conference on Nanotechnology - IEEE NANO 2016 - Sendai, Japan
継続期間: 2016 8 222016 8 25

出版物シリーズ

名前16th International Conference on Nanotechnology - IEEE NANO 2016

Other

Other16th IEEE International Conference on Nanotechnology - IEEE NANO 2016
国/地域Japan
CitySendai
Period16/8/2216/8/25

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 原子分子物理学および光学

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