Inhibitory interaction of c-Myb and GATA-1 via transcriptional co-activator CBP

Tomomi Takahashi, Naruyoshi Suwabe, Ping Dai, Masayuki Yamamoto, Shunsuke Ishii, Toru Nakano

研究成果: Article査読

42 被引用数 (Scopus)

抄録

Gene targeting experiments have revealed that transcription factors such as c-Myb and GATA-1 play crucial roles during hematopoietic differentiation. c-Myb is necessary in the immature cells of almost every hematopoietic lineage and GATA-1 is essential for the development of the erythroid lineage. In addition, CREB-binding protein (CBP) acts as a transcriptional adapter for various transcription factors, including c-Myb and GATA-1. In this paper, we show that the transcription factors c-Myb and GATA-1 each inhibit the transcriptional activity of the other and that any possible bipartite complexes c-Myb, GATA-1, and CBP could be formed, but the tripartite complex was hardly formed. The exclusive binding of GATA-1 and c-Myb to CBP is probably the molecular basis for the mutual inhibition of their transcriptional activity. Our data suggest that cross-talk between these three factors might be important for hematopoietic differentiation and that CBP functions as a key molecule during the process.

本文言語English
ページ(範囲)134-140
ページ数7
ジャーナルOncogene
19
1
DOI
出版ステータスPublished - 2000 1 6
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 遺伝学
  • 癌研究

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