Inhibitory effect of quinaldic acid on glucose-induced insulin release from isolated Langerhans islets of the rat

Hiroshi Okamoto, Susumu Miyamoto, Hiroshi Mabuchi, Ryoyu Takeda

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Influence of quinaldic acid on glucose-induced insulin release from isolated Langerhans islets of rats was studied. Glucose, in high concentration (15 mM), stimulated insulin release for 30 min after incubation (the first phase), followed by distinctly increasing release during the subsequent 60 min (the second phase). Addition of 12 mM quinaldic acid to an incubation medium containing 15 mM glucose caused almost complete inhibition in the second phase of glucose-induced insulin release, while the first phase was insensitive to quinaldic acid. A possible mechanism concerning the effect of quinaldic acid on β-cells of Langerhans islets is discussed.

本文言語English
ページ(範囲)623-629
ページ数7
ジャーナルBiochemical and biophysical research communications
59
2
DOI
出版ステータスPublished - 1974 7 24
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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