Inhibitory effect of neutralization of macrophage colony-stimulating factor in mechanical loading-induced osteoclastogenesis and odontoclastogenesis

Hideki Kitaura, Keisuke Kimura, Masahiko Ishida, Zaki Hakami, Saeed Jafari, Haruki Sugisawa, Harika Kohara, Masako Yoshimatsu, Teruko Takano-Yamamoto T

研究成果: Article査読

抄録

Orthodontic tooth movement is achieved by the process of repeated alveolar bone resorption by osteoclasts. However, orthodontic force-induced root resorption by odontoclasts leads to serious problems. We established mechanical loading-induced tooth movement in a mouse model, in which a nickel-titanium coil spring was inserted between the upper incisors and the upper first molar. Macrophage colony-stimulating factor (M-CSF) is essential for osteoclastogenesis and odontoclastogenesis. We examined the effect of neutralization of M-CSF on mechanical loading-induced osteoclastogenesis and odontoclastogenesis in the mouse model. Mice were injected locally with M-CSF neutralization antibodies during mechanical loading-induced tooth movement. The number of osteoclasts and odontoclasts were counted in horizontal sections of the upper first molar after staining with tartrate-resistant acid phosphatase. The neutralization of M-CSF significantly inhibited osteoclastogenesis and odontoclastogenesis. These results suggested that the neutralization of M-CSF might be useful in controlling orthodontic tooth movement and root resorption.

本文言語English
ページ(範囲)O-208-O-209
ジャーナルTransactions of Japanese Society for Medical and Biological Engineering
52
DOI
出版ステータスPublished - 2014 8 17

ASJC Scopus subject areas

  • Biomedical Engineering

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