Inhibition of the Ca2v+-activated K+-channel by sapecin B, an insect antibacterial protein

Masafumi Shimoda, Hiroshi Takagi, Shoichiro Kurata, Tohru Yoshioka, Shunji Natori

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Sapecin is an antibacterial protein of the flesh fly and sapecin B is its homologue structurally similar to charybdotoxin of scorpion venom, which is known to be a K+ channel inhibitor. We found that, like charybdotoxin, sapecin B inhibits part of the voltage pulse-induced K+ currents of rat cerebellar Purkinje cells. We suggest that this effect is due to inhibition of the Ca+-activated K+ channel. Probably, sapecin B is a naturally occurring K+ channel inhibitor as well as an antibacterial protein.

本文言語English
ページ(範囲)59-62
ページ数4
ジャーナルFEBS Letters
339
1-2
DOI
出版ステータスPublished - 1994 2月 14
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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