Inhibition of estrogen actions in human gynecological malignancies: New aspects of endocrine therapy for endometrial cancer and ovarian cancer

Kiyoshi Ito, Hiroki Utsunomiya, Hitoshi Niikura, Nobuo Yaegashi, Hironobu Sasano

研究成果: Review article査読

27 被引用数 (Scopus)

抄録

Endometrial carcinoma and possibly ovarian carcinoma are considered "estrogen-dependent tumors" in human gynecological malignancies. In endometrial carcinoma, the enzymes responsible for intratumoral estrogen metabolism and biosynthesis are different from those in human breast carcinoma, although both of them are considered "estrogen-dependent malignancies" Specific and effective endocrine treatment of endometrial carcinoma should be explored, although progestin agents have been widely used for a long time. Aromatase inhibitors, the most effective endocrine agents of breast carcinoma, retinoids, metabolites of vitamin A, and synthetic peroxisome proliferator-activated receptor (PPAR) gamma ligands, used for the treatment of insulin resistance in type II diabetes mellitus, may be the important candidates for possible endocrine treatment of endometrial carcinoma.In ovarian carcinoma, several clinical studies recently demonstrated that aromatase inhibitors had some therapeutic activity against recurrent ovarian carcinoma. However, at least at this juncture, further studies should be required to establish an aromatase inhibitor treatment as one form of endocrine therapy of ovarian carcinoma in future.

本文言語English
ページ(範囲)161-167
ページ数7
ジャーナルMolecular and Cellular Endocrinology
340
2
DOI
出版ステータスPublished - 2011 7 4

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 内分泌学

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