Inhibition by morphine of the cardiovascular and behavioral responses evoked by centrally administered substance P in conscious rats

K. Itoi, N. Jost, C. Tschöpe, J. Culman, E. Badoer, Th Unger

研究成果: Article査読

5 被引用数 (Scopus)

抄録

The effect of endogenous opioid receptor stimulation on the central cardiovascular and behavioral actions of substance P (SP) was examined in conscious rats. SP (55 pmol) injected intracerebroventricularly (i.c.v.) elicited increases in mean arterial pressure, heart rate, and stereotyped behavioral activation such as exploring and grooming, which were considered to be parts of the cardiovascular defense reaction. Intravenous (i.v.) pretreatment with morphine (2.5 and 5.0 mg/kg) attenuated the cardiovascular and behavioral responses produced by SP i.c.v. dose-dependently. The i.v. pretreatment with naloxone (10 mg/kg) had no effect on the central SP-induced response. Presser responses elicited by i.c.v. injection of corticotropin-releasing factor or angiotensin II were also attenuated by pretreatment with i.v. morphine (5.0 mg/kg). Our results showed that endogenous opioid receptor stimulation antagonizes the central cardiovascular and behavioral actions of SP. Morphine may not influence the primary site of action of SP but does influence the central neural pathway which conveys the SP-induced sympathetic activation signal.

本文言語English
ページ(範囲)181-187
ページ数7
ジャーナルNeuropharmacology
33
2
DOI
出版ステータスPublished - 1994 2月

ASJC Scopus subject areas

  • 薬理学
  • 細胞および分子神経科学

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