Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary

Akira Sakurada, Akihiko Suzuki, Masami Sato, Hiromitsu Yamakawa, Kazuhiko Orikasa, Shinji Uyeno, Tetsuya Ono, Noriaki Ohuchi, Shigefumi Fujimura, Akira Horii

研究成果: Article査読

100 被引用数 (Scopus)

抄録

In the present study, we searched for genetic alterations of the entire coding region of PTEN/MMAC1, a recently isolated candidate tumor suppressor gene, in 178 specimens from Japanese patients with various malignant tumors by the polymerase chain reaction-single strand conformation polymorphism method. The samples consisted of 11 glioblastoma multiformes (GBMs), 14 astrocytomas, 47 breast cancers, 25 non-small cell lung cancers, 9 small cell lung cancers, 8 pancreatic cancers, 24 renal cell carcinomas, 20 ovarian cancers, and 20 metastatic lung tumors from various organs. Only one somatic frameshift mutation at codon 319 was observed in one (9%) of eleven GBMs. Our results suggest that mutation of the PTEN/MMAC1 gene does not play a major role in carcinogenesis, at least in the tumor types from Japanese patients analyzed in this study.

本文言語English
ページ(範囲)1025-1028
ページ数4
ジャーナルJapanese Journal of Cancer Research
88
11
DOI
出版ステータスPublished - 1997 11

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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