Inductive effect of Porphyromonas gingivalis fimbriae on differentiation of human monocytic tumor cell line U937

K. Hirose, Emiko Isogai, H. Mizugai, H. Miura, I. Ueda

研究成果: Article査読

6 被引用数 (Scopus)

抄録

This study used the human monocytic tumor cell line U937 to examine whether Porphyromonas gingivalis fimbriae induce differentiation of monocyte/macrophage progenitors. When the progenitor cells were incubated with P. gingivalis fimbriaè, the incubation resulted in increased Fc rosette formation and increased CD11b production by the cells. The presence of a protein kinase C inhibitor, H7 or calphostin C, in the medium eliminated the stimulatory effects of P. gingivalis fimbriae on Fc rosette formation. Furthermore. CD11b expression was inhibited by calphostin C. In contrast, HA1004, an inhibitor of cyclic nucleotide-dependent protein kinase. had no effect on P. gingivalis fimbriae-induced Fc rosette formation or CD11b expression. These results demonstrate that P. gingivalis fimbriae are a potent inducer of the differentiation of the monocyte/macrophage tumor cell line U937, most probably via cyclic nucleotide-independent protein kinase C.

本文言語English
ページ(範囲)62-64
ページ数3
ジャーナルOral Microbiology and Immunology
11
1
DOI
出版ステータスPublished - 1996 1 1

ASJC Scopus subject areas

  • 微生物学
  • 免疫学
  • 歯科学(全般)
  • 微生物学(医療)

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