Induction of thymic stromal lymphopoietin in mesenchymal stem cells by interaction with myeloma cells

Shinji Nakajima, Tohru Fujiwara, Hiroto Ohguchi, Yasushi Onishi, Mayumi Kamata, Yoko Okitsu, Noriko Fukuhara, Kenichi Ishizawa, Hideo Harigae

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Recently, the bone marrow (BM) microenvironment has been reported to support the survival of multiple myeloma (MM) cells. In this study, we examined changes in gene expression profile in human mesenchymal stem cells (MSCs) by co-culture with MM cells. cDNA array analysis indicated that co-culture induced multiple factors which have positive effects on the survival of MM cells, such as interleukin-6 (IL-6) and insulin-like growth factor-1. Other than these factors, thymic stromal lymphopoietin (TSLP), which is a cytokine involved in the progression of pancreatic and breast cancer through induction of T helper 2 cell responses, was up-regulated in MSCs. TSLP exhibited no effect on proliferation or drug resistance of MM cells, but TSLP secreted from MSCs by co-culture expanded IL-13+ CD4+ T cells through stimulation of dendritic cells. These results suggested that MM cells positively act to induce various molecules in MSCs, leading to the formation of a more advantageous BM microenvironment for their survival.

本文言語English
ページ(範囲)2605-2613
ページ数9
ジャーナルLeukemia and Lymphoma
55
11
DOI
出版ステータスPublished - 2014 11 1

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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