Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis

K. Abe, L. H. Pan, M. Watanabe, T. Kato, Y. Itoyama

研究成果: Article査読

226 被引用数 (Scopus)

抄録

Spinal cords of sporadic cases with amyotrophic lateral sclerosis (ALS) and normal controls were immunohistochemically examined using antibodies for Cu/Zn superoxide dismutase (SOD) and nitrotyrosine (NT). Immunoreactivity for Cu/Zn SOD of the motor neurons was not different between the ALS and controls. In contrast, immunoreactivity for NT was densely detected in motor neurons of ALS but was not or was only minimally detected in those of controls. The staining was also found in the axons of motor neurons of ALS, but was not found in the controls. These results suggest that nitration of protein-tyrosine residue is upregulated in motor neurons of the spinal cord of ALS.

本文言語English
ページ(範囲)152-154
ページ数3
ジャーナルNeuroscience Letters
199
2
DOI
出版ステータスPublished - 1995 10月 20
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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