Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation

Tomosada Sugimoto, Yi Fen He, Makoto Funahashi, Hiroyuki Ichikawa

研究成果: Article査読

23 被引用数 (Scopus)

抄録

c-fos and zif268 expression were assessed by immunocytochemistry for c- Fos and Zif268 proteins in the sensory trigeminal nuclear complex following noxious mechanical stimulation of the mandibular incisor pulp of rats. Marked up-regulation of both immediate early genes was observed in the subnucleus oralis ipsilateral to the stimulation. Cavity preparation of the dentine without reaching the pulp did not cause significant up-regulation detectable by immunocytochemistry. These results provide evidence that noxious dental signals reach the ipsilateral subnucleus oralis and up-regulate the transcription of immediate early genes c-fos and zif268.

本文言語English
ページ(範囲)353-358
ページ数6
ジャーナルBrain research
794
2
DOI
出版ステータスPublished - 1998 6 1
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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