Since it became clear that heme oxygenase-1 (HO-1) is a powerful anti- oxidant, many important reports on this topic have been published HO-1 is transcriptionally induced under various stresses as an acute phase protein. Such cytokines as IL-1β, IL-6, and TNF-α, which can induce the HO-1 gene, are produced in the epithelial cells of airways. They exacerbate asthma and other chronic respiratory diseases by causing inflammation in airways. Analysis of the group of cis-elements 5'-upstream of the HO-1 gene suggests that HO-1 is induced by a viral infection which also exacerbates asthma. Indeed, transcription of the HO-1 gene is upregulated in clutured cells after infection by human rhinovirus type 14. Moreover, both cells treated with heroin to accumulate HO-1 protein and cells in which the HO-1 gene was introduced to express HO-1 protein stably were less susceptible to viral infection than were untreated cells. These results suggest that HO-1 has an anti-viral effect.
|ジャーナル||Japanese Journal of Thoracic Diseases|
|出版ステータス||Published - 1997|
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