Induction of brain-derived neurotrophic factor (BDNF) and the receptor trk B mRNA following middle cerebral artery occlusion in rat

Shouichi Arai, Hiroyuki Kinouchi, Atsuya Akabane, Yuji Owada, Hideyuki Kamii, Makoto Kawase, Takashi Yoshimoto

研究成果: Article査読

54 被引用数 (Scopus)

抄録

Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced brain-derived neurotrophic factor (BDNF) and the receptor, trk 13 mRNA, in brain. In situ hybridization studies showed that BDNF and trk B mRNAs were induced in a widespread region of the ipsilateral cortex outside the infarct at 4 h following MCA occlusion. They were also induced in the bilateral hippocampi which are remote from the ischemic MCA region. These data show that changes in neurotrophic factor and receptor gene expressions can occur in the areas outside the infarct which could survive.

本文言語English
ページ(範囲)57-60
ページ数4
ジャーナルNeuroscience Letters
211
1
DOI
出版ステータスPublished - 1996 6 14

ASJC Scopus subject areas

  • 神経科学(全般)

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