Induction of antenatal periventricular leukomalacia by hemorrhagic hypotension in the chronically instrumented fetal sheep

Tadashi Matsuda, Kazuhiko Okuyama, Kazutoshi Cho, Nobuhiko Hoshi, Yoshinori Matsumoto, Yoshiyasu Kobayashi, Seiichiro Fujimoto

研究成果: Article査読

43 被引用数 (Scopus)

抄録

OBJECTIVES: Our purpose was to determine whether systemic hypotension induced by rapid withdrawal of fetal blood would induce periventricular leukomalacia in the brain of premature fetal sheep. STUDY DESIGN: At 113 days' gestation, systemic hypotension (mean blood pressure <30 mm Hg) was induced by withdrawing approximately 35% of the fetoplacental blood volume in the hemorrhage group (n = 6), whereas in the control group (n = 4) isovolemic exchange transfusion was carried out. Six days after the insult, fetal brains were removed and processed for histologic analysis. RESULTS: Five of the 6 fetuses in the hemorrhage group exhibited periventricular white-matter lesions, consisting of nodular coagulation necrosis or diffuse axonal swellings or both. No abnormal findings other than these lesions were detected in the fetal brains in either experimental group. CONCLUSION: Hemorrhagic hypotension antenatally induced brain lesions similar to those of periventricular leukomalacia, suggesting that it is an essential element in the pathogenesis of periventricular leukomalacia in premature fetuses.

本文言語English
ページ(範囲)725-730
ページ数6
ジャーナルAmerican Journal of Obstetrics and Gynecology
181
3
DOI
出版ステータスPublished - 1999
外部発表はい

ASJC Scopus subject areas

  • 産婦人科学

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