Indomethacin Inhibits the Antihypertensive Effect of Captopril, SQ 14225, in Low Renin Hypertension

Keishi Abe, Toru Itoh, Yutaka Imai, Makito Sato, Toshikazu Goto, Yoichi Otsuka, Kaoru Yoshinaga

研究成果: Article査読

6 被引用数 (Scopus)

抄録

The antihypertensive mechanism of orally active angiotensin I-converting enzyme inhibitor, SQ 14225 (SQ), in low renin hypertension was investigated. In the SQ-responder with low renin hypertension, the hypotensive effect of SQ was abolished after the inhibition of endogenous prostaglandin (PG) synthesis with indomethacin, while no significant change in blood pressure was found in the SQ-responder with normal renin hypertension. These results suggest that SQ may potentiate the vasodilating PG system, contributing to the antihypertensive mechanism in SQ responders with low renin hypertension.

本文言語English
ページ(範囲)117-118
ページ数2
ジャーナルthe tohoku journal of experimental medicine
132
1
DOI
出版ステータスPublished - 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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