Increased ratio of soluble fibrin formation/thrombin generation in patients with DIC

Shigeki Kushimoto, Hideo Wada, Kazuo Kawasugi, Kohji Okamoto, Toshimasa Uchiyama, Yoshinobu Seki, Tsuyoshi Hatada, Hiroshi Imai, Tsutomu Nobori

研究成果: Article査読

5 被引用数 (Scopus)

抄録

The generation of thrombin-antithromin (AT) complex (TAT) or soluble fibrin (SF) was prospectively compared with prothrombin fragment 1 + 2 (F1 + 2) generation in patients with disseminated intravascular coagulation (DIC). The plasma levels of TAT, SF, and F1 + 2 were significantly higher in the DIC group than in the non-DIC group. The differences in these levels between the DIC group and non-DIC group were significantly related to infections and hematopoietic tumors. There were no significant differences in the TAT/F1 + 2 ratio between DIC and non-DIC patients, but the SF/F1 + 2 ratio was significantly higher in the DIC group than the non-DIC group. The plasma AT activity was significantly higher in patients with DIC with resolution than in those without resolution, and in survivors than in nonsurvivors. These findings suggest that the ratio of TAT/thrombin is constant between the patients with and without DIC but that the ratio of fibrin formation/thrombin might increase in DIC.

本文言語English
ページ(範囲)628-632
ページ数5
ジャーナルClinical and Applied Thrombosis/Hemostasis
18
6
DOI
出版ステータスPublished - 2012 11

ASJC Scopus subject areas

  • Hematology

フィンガープリント 「Increased ratio of soluble fibrin formation/thrombin generation in patients with DIC」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル