Increased phagocytosis of platelets from patients with secondary dengue virus infection by human macrophages

Shoko Honda, Mariko Saito, Efren M. Dimaano, Philip A. Morales, Maria T.G. Alonzo, Lady Anne C. Suarez, Natsuki Koike, Shingo Inoue, Atsushi Kumatori, Ronald R. Matias, Filipinas F. Natividad, Kazunori Oishi

研究成果: Article査読

37 被引用数 (Scopus)

抄録

The relationship between the percent phagocytosis of platelets by differentiated THP-1 cells was examined using flowcytometry and the peripheral platelet counts as well as platelet-associated IgG (PAIgG) in 36 patients with secondary dengue virus (DV) infections. The percent phagocytosis and the levels of PAIgG were significantly increased in these patients during the acute phase compared with the healthy volunteers. The increased percent phagocytosis and PAIgG found during the acute phase significantly decreased during the convalescent phase. An inverse correlation between platelet count and the percent phagocytosis (P=0.011) and the levels of PAIgG (P=0.041) was found among these patients during the acute phase. No correlation was found, however, between the percent phagocytosis and the lev-els of PAIgG. Our present data suggest that accelerated platelet phagocytosis occurs during the acute phase of secondary DV infections, and it is one of the mechanisms of thrombocytopenia in this disease.

本文言語English
ページ(範囲)841-845
ページ数5
ジャーナルAmerican Journal of Tropical Medicine and Hygiene
80
5
DOI
出版ステータスPublished - 2009 5月
外部発表はい

ASJC Scopus subject areas

  • 寄生虫科
  • ウイルス学
  • 感染症

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