Increased Intratumor Concentration of Fluorescein‐isothiocyanate‐labeled Neocarzino‐statin in Rats under Angiotensin‐induced Hypertension

Ikuo Abe, Katsuyoshi Hori, Sachiko Saito, Shigeru Tanda, Yulin Li, Maroh Suzuki

研究成果: Article

26 引用 (Scopus)

抜粋

On the basis of the observation that the tumor tissue blood flow selectively increases under angiotensin (AT)‐induced hypertension, the change of the drug concentration in the tumor and normal tissues was examined in male Donryu rats. The intratumor concentration of fluorescein isothiocyanate‐labeled neocarzinostatin was about 2‐fold higher in the AT‐induced hypertension group than in the control up to 20 min after the drug injection. In the normal organs or the uninvolved organs of the tumor‐bearing rats, however, no clear increase was seen in the experimental group compared with the control, as anticipated from the observation of the tissue blood flow. The present study supports the hypothesis that the enhanced anticancer effect in chemotherapy under AT‐induced hypertension formerly reported is due to the tumor‐selective enhancement of the drug delivery.

元の言語English
ページ(範囲)874-879
ページ数6
ジャーナルJapanese Journal of Cancer Research
79
発行部数7
DOI
出版物ステータスPublished - 1988 7

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

フィンガープリント Increased Intratumor Concentration of Fluorescein‐isothiocyanate‐labeled Neocarzino‐statin in Rats under Angiotensin‐induced Hypertension' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用