Increased Energy Expenditure, Dietary Fat Wasting, and Resistance to Diet-Induced Obesity in Mice Lacking Renin

Nobuyuki Takahashi, Feng Li, Kunjie Hua, Jianbei Deng, Chih Hong Wang, Robert R. Bowers, Timothy J. Bartness, Hyung Suk Kim, Joyce B. Harp

研究成果: Article査読

82 被引用数 (Scopus)

抄録

An overactive renin-angiotensin system is associated with obesity and the metabolic syndrome. However, the mechanisms behind it are unclear. Cleaving angiotensinogen to angiotensin I by renin is a rate-limiting step of angiotensin II production, but renin is suggested to have angiotensin-independent effects. We generated mice lacking renin (Ren1c) using embryonic stem cells from C57BL/6 mice, a strain prone to diet-induced obesity. Ren1c-/- mice are lean, insulin sensitive, and resistant to diet-induced obesity without changes in food intake and physical activity. The lean phenotype is likely due to a higher metabolic rate and gastrointestinal loss of dietary fat. Most of the metabolic changes in Ren1c-/- mice were reversed by angiotensin II administration. These results support a role for angiotensin II in the pathogenesis of diet-induced obesity and insulin resistance.

本文言語English
ページ(範囲)506-512
ページ数7
ジャーナルCell Metabolism
6
6
DOI
出版ステータスPublished - 2007 12 5
外部発表はい

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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