Rationale: Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) Increase In Inflammatory pulmonary diseases. Objectives: To study whether arterial Hb-CO Is useful to monitor disease activity In patients with chronic obstructive pulmonary disease (COPD) who had stopped smoking. Methods: We measured arterial Hb-CO, arterlovenous Hb-CO differences, and FEV, In 58 patients with COPD and 61 ex-smoking control subjects. Results: Arterial Hb-CO concentrations In patients at stable conditions were higher than those In control subjects (p < 0.0001). Furthermore, the Hb-CO concentrations In patients at the exacerbations (p < 0.0001) were higher than those at the stable conditions. Arterial Hb-CO concentrations In patients at stage III were higher than those In patients at stage II, and the Hb-CO concentrations In patients at stage IV were higher than those in patients at stage III at the stable conditions and exacerbations. Arterial Hb-CO correlated with exhaled CO In patients with COPD at stage II and stage III at the exacerbations. Arterial Hb-CO inversely correlated with the arterial blood partial oxygen pressure and FEV1. Arterlovenous Hb-CO differences in patients at the exacerbations did not differ from those In patients at stable conditions and from those In control subjects. Moreover, arterial Hb-CO correlated with serum C-reactive protein values and serum lipld peroxide concentrations. Conclusions: These findings suggest that increased arterial Hb-CO may relate to severity In patients with COPD because of lung and systemic inflammation and production of reactive oxygen species.
|ジャーナル||American journal of respiratory and critical care medicine|
|出版ステータス||Published - 2005 6 1|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine