Increase of complement fragment C5a in cerebrospinal fluid during exacerbation of neuromyelitis optica

Hiroshi Kuroda, Kazuo Fujihara, Rina Takano, Yoshiki Takai, Toshiyuki Takahashi, Tatsuro Misu, Ichiro Nakashima, Shigeru Sato, Yasuto Itoyama, Masashi Aoki

研究成果: Article査読

35 被引用数 (Scopus)

抄録

Complement is thought to play a pivotal role in neuromyelitis optica (NMO) pathogenesis. Anaphylatoxins (C3a, C4a, and C5a), produced in complement activation, have proinflammatory potential, and thereby may play an important role. We measured concentrations of anaphylatoxins in CSF and sera, obtained from patients with NMO (n = 15), multiple sclerosis (MS) (n = 15), and other neurological disease (OND) (n = 12), and evaluated their clinical implications. The CSF-C5a levels were elevated significantly in NMO patients, especially in patients with multiple enhanced lesions on MRI. The CSF-C5a levels correlated with the severity of exacerbation. Our results may provide a rationale for anti-complement therapies of NMO.

本文言語English
ページ(範囲)178-182
ページ数5
ジャーナルJournal of Neuroimmunology
254
1-2
DOI
出版ステータスPublished - 2013 1 15

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 神経学
  • 臨床神経学

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