Incidence and characterization of age related amyloid deposits in the human anterior pituitary gland

Takatoshi Tashima, Tetsuyuki Kitamoto, Jun Tateishi, Koji Ogomori, Hiroyuki Nakagaki

研究成果: Article査読

21 被引用数 (Scopus)

抄録

To identify amyloid deposits in the anterior pituitary gland, we have immunohistochemical, histochemical and alkaline Congo red staining. The anti-human P component reacted positively with these amyloid deposits, while antisera against prealbumin, AA type amyloid fibril protein and various anterior pituitary hormones were negative. A combination of Congo red and anti-human P component staining was most sensitive and reliable for detection of amyloid in the anterior pituitary glands of 300 randomly autopsied patients. Amyloid deposits increased in parallel with the age of the patients, however, they appeared earlier and more frequently than heretofore reported. Deposition of amyloid was seen initially in the 3rd decade and the positivity rate of amyloid deposits was 73% in the 5th decade. The histochemical characteristics of these pituitary amyloid deposits differed from those of cerebral and systemic deposits, particularly those found in the amyloid of senile systemic amyloidosis.

本文言語English
ページ(範囲)323-327
ページ数5
ジャーナルVirchows Archiv A Pathological Anatomy and Histopathology
412
4
DOI
出版ステータスPublished - 1988 7 1
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学

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