Inactivation of sars-cov-2 by catechins from green tea

Hidekazu Nishimura, Michiko Okamoto, Isolde Dapat, Masanori Katsumi, Hitoshi Oshitani

研究成果: Article査読

7 被引用数 (Scopus)


Green tea extracts effectively inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro in a dose-dependent manner. Ten-fold serially diluted solutions of catechin mixture reagent from green tea were mixed with the viral culture fluid at a volume ratio of 9:1, respectively, and incubated at room temperature for 5 min. The solution of 10 mg/mL catechin reagent reduced the viral titer by 4.2 log and 1.0 mg/mL solution by one log. Pre-infection treatment of cells with the reagent alone did not affect viral growth. In addition, cells treated with only the reagent were assayed for host cell viability using the WST-8 system, and almost no host cell damage by the treatment was observed. These findings suggested that the direct treatment of virus with the reagent before inoculation decreased the viral activity and that catechins might have the potential to suppress SARS-CoV-2 infection.

ジャーナルJapanese journal of infectious diseases
出版ステータスPublished - 2021

ASJC Scopus subject areas

  • 微生物学(医療)
  • 感染症


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