In vivo transdermal delivery using a shock tube

S. Lee, D. J. McAuliffe, T. Kodama, A. G. Doukas

研究成果: Article査読

11 被引用数 (Scopus)

抄録

A shock tube was utilized for transdermal delivery in fuzzy rats. Rhodamine-B dextran, 10 kDa molecular weight, was used as the probe molecule. Shock waves were generated by a two-stage shock tube. A single shock wave was applied onto the skin to permeabilize the stratum corneum. Subsequently, the dextran solution diffused through the stratum corneum into the epidermis. Fluorescence microscopy of biopsies showed that the dextran was delivered to a depth of 30-60 μm into the skin. Thus, the shock tube could become an inexpensive device for transdermal drug delivery.

本文言語English
ページ(範囲)307-311
ページ数5
ジャーナルShock Waves
10
5
DOI
出版ステータスPublished - 2000 1月 1
外部発表はい

ASJC Scopus subject areas

  • 機械工学
  • 物理学および天文学(全般)

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