In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

Tatsuhiro Yamamoto, Kenjiro Ikuta, Keiji Oi, Kohtaro Abe, Toyokazu Uwatoku, Fuminori Hyodo, Masaharu Murata, Noboru Shigetani, Kengo Yoshimitsu, Hiroaki Shimokawa, Hideo Utsumi, Yoshiki Katayama

研究成果: Article査読

13 被引用数 (Scopus)

抄録

A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.

本文言語English
ページ(範囲)2787-2790
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
14
11
DOI
出版ステータスPublished - 2004 6 7

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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