In vivo measurements of change in viscoelasticity of arterial wall during the flow-mediated dilation

Hiroshi Kanai, Hideyuki Hasegawa, Kazuki Ikeshita

研究成果: Conference contribution

抄録

The present paper introduces in vivo measurements of viscoelasticity of arterial wall developed in our laboratory. The endothelial dysfunction is considered to be an earliest stage of atherosclerosis. Moreover, it was reported that the smooth muscle, which constructs the media of the artery, changes its characteristics due to atherosclerosis. Therefore, it is essential to develop an in vivo measurement method to assess the regional endothelial function and mechanical property (viscoelasticity) of the arterial wall. To evaluate the endothelial function, there is a conventional technique for measuring the transient change in the diameter of the brachial artery caused by flow mediated dilation (FMD) after the release of avascularization. However, this method does not directly evaluate the viscoelasticity of the intima-media region of the arterial wall. In the present paper, therefore, we proposed a method for simultaneous measurement of waveforms of the radial strain and blood pressure at the radial artery, and we developed its measurement system. From in vivo experiments, the viscoelasticity parameters of the arterial wall were estimated from the measured stress-strain relationship (hysteresis loop) using the least-square method and their transient changes after the release of avascularization were revealed. For healthy young persons, the slope of the hysteresis loop decreased due to the FMD, which corresponds to decrease in the elastic modulus. At the same time, the area of the loop increased after recirculation, which corresponds to the increase of the ratio of the loss modulus (viscosity) to the elastic modulus when the Voigt model is assumed. These results show a potential of the proposed method for thorough analysis of the transient change in viscoelasticity due to FMD.

本文言語English
ホスト出版物のタイトルProceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009
出版社American Society of Mechanical Engineers (ASME)
ページ515-521
ページ数7
ISBN(印刷版)9780791843758
DOI
出版ステータスPublished - 2010 1月 1
イベント2009 ASME International Mechanical Engineering Congress and Exposition, IMECE2009 - Lake Buena Vista, FL, United States
継続期間: 2009 11月 132009 11月 19

出版物シリーズ

名前ASME International Mechanical Engineering Congress and Exposition, Proceedings
2

Other

Other2009 ASME International Mechanical Engineering Congress and Exposition, IMECE2009
国/地域United States
CityLake Buena Vista, FL
Period09/11/1309/11/19

ASJC Scopus subject areas

  • 機械工学

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