[In vivo experimental models of neuromyelitis optica]

研究成果: Article

抜粋

Neuromyelitis optica (NMO) is autoimmune disease targeting against water channel aquaporin 4 (AQP4), mainly located at astrocyte foot processes in the central nervous system (CNS). The basis of NMO pathology is the astrocytopathy, but it is recently revealed that there is the diversity of NMO lesion possibly links to the mechanism of astrocyte death with and without complement. In vitro and in vivo models of NMO suggested that this autoantibody is pathogenic. There are mainly two types of in vivo experimental rodent models of NMO, one is a model of direct intracranial injection of NMO-IgG and the other is a passive transfer of NMO-IgG in experimental autoimmune encephalomyelitis (EAE). Both is useful to study the pathogenicity of NMO-IgG, and is promising to create the new generation therapy for autoimmune CNS diseases.

元の言語English
ページ(範囲)1941-1948
ページ数8
ジャーナルNihon rinsho. Japanese journal of clinical medicine
72
発行部数11
出版物ステータスPublished - 2014 11 1
外部発表Yes

ASJC Scopus subject areas

  • Medicine(all)

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