In vitro heat generation by ferrimagnetic maghemite microspheres for hyperthermic treatment of cancer under an alternating magnetic field

Masakazu Kawashita, Shinjiro Domi, Yasuhiro Saito, Masaaki Aoki, Yukihiro Ebisawa, Tadashi Kokubo, Takashi Saito, Mikio Takano, Norio Araki, Masahiro Hiraoka

研究成果: Article査読

41 被引用数 (Scopus)

抄録

Ferrimagnetic materials can be expected to be useful as thermo seeds for hyperthermic treatment of cancer, especially where the cancer is located in deep parts of body, as they can generate heat by magnetic hysteretic loss when they are placed in an alternating magnetic field. Recently, it was reported that ferrimagnetic maghemite (γ-Fe2O3) microspheres 20-30 μm in diameter prepared in aqueous solution can show excellent heat generating ability. However, these microspheres have many cracks on their surfaces. In this study, the preparation conditions for the microspheres was further optimized in order to obtain crack-free ferrimagnetic microspheres, and the in vitro heat generation of the obtained microspheres was measured in an agar phantom under an alternating magnetic field. Crack-free γ-Fe 2O3 microspheres 20-30 μm in diameter were obtained successfully. Their saturation magnetization and coercive force were 68 emu g-1 and 198 Oe, respectively. Their heat generation under an alternating magnetic field of 300 Oe at 100 kHz was estimated to be 42 W g -1. The microspheres showed in vitro heat generation when they were dispersed in an agar phantom and placed under an alternating magnetic field. It is believed that these microspheres may be useful for the in situ hyperthermic treatment of cancer.

本文言語English
ページ(範囲)1897-1903
ページ数7
ジャーナルJournal of Materials Science: Materials in Medicine
19
5
DOI
出版ステータスPublished - 2008 5

ASJC Scopus subject areas

  • 生物理学
  • バイオエンジニアリング
  • 生体材料
  • 生体医工学

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