In vitro assessment of poly(methylmethacrylate)-based bone cement containing magnetite nanoparticles for hyperthermia treatment of bone tumor

Zhixia Li, Koki Kawamura, Masakazu Kawashita, Tada Aki Kudo, Hiroyasu Kanetaka, Masahiro Hiraoka

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Poly(methylmethacrylate) (PMMA)-based cements containing magnetite (C-PMMA/Fe3O4) is useful in hyperthermia treatment for bone tumor. We have prepared C-PMMA/Fe3O4 by incorporating Fe3O4 powders of different diameters (means of 300, 35, and 11 nm) into the polymerization reaction of methyl methacrylate monomer to develop a new bone cement with high heating efficiencies in alternating current (AC) magnetic fields. Further, we have investigated the in vitro heating capability of the cements in different AC magnetic fields. The mechanical strength and biocompatibility of the resultant cements were also assessed. Their heat generation strongly depends on the magnetite nanoparticle sizes and applied magnetic fields. The cement containing Fe3O4 with mean diameter around 35 nm exhibited the highest heating capability in AC magnetic fields of 120 and 300 Oe at 100 kHz while that with mean diameter around 11 nm exhibited optimum heating capability in AC magnetic fields of 40 Oe at 600 kHz. The incorporation of Fe3O4 into cement-30 wt % of the total amount of cement-did not significantly change the compressive strength of cement, and the proliferation of rat fibroblast Rat-1 cells on cement discs was not inhibited. Our investigations are useful for designing new PMMA/Fe3O4 bone cement with high heating efficiencies and biocompatibilities for bone tumor treatments.

本文言語English
ページ(範囲)2537-2545
ページ数9
ジャーナルJournal of Biomedical Materials Research - Part A
100 A
10
DOI
出版ステータスPublished - 2012 10月

ASJC Scopus subject areas

  • セラミックおよび複合材料
  • 生体材料
  • 生体医工学
  • 金属および合金

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