In situ production of sex steroids in human breast carcinoma

Takashi Suzuki, Yasuhiro Miki, Takuya Moriya, Jun Ichi Akahira, Hisashi Hirakawa, Noriaki Ohuchi, Hironobu Sasano

研究成果: Review article査読

35 被引用数 (Scopus)

抄録

It is well known that sex steroids are closely involved in the growth of human breast carcinomas, and the great majority of breast carcinomas express sex steroid receptors. In particular, recent studies have demonstrated that estrogens and androgens are locally produced and act in breast carcinoma tissues without release into plasma. Blockade of intratumoral estrogen production potentially leads to an improvement in the prognosis of invasive breast carcinoma patients, and, therefore, it is important to obtain a better understanding of sex steroid-producing enzymes in breast carcinoma. In this review, we summarize recent studies on tissue concentration of sex steroids and expression of enzymes related to intratumoral production of estrogens [aromatase, steroid sulfatase (STS), and 17β-hydroxysteroid dehydrogenase type 1 (17βHSD1)], and androgens (17βHSD5 and 5α-reductase) in invasive and in situ (noninvasive) breast carcinomas, and discuss the significance of intratumoral production of sex steroids in breast carcinoma.

本文言語English
ページ(範囲)121-127
ページ数7
ジャーナルMedical Molecular Morphology
40
3
DOI
出版ステータスPublished - 2007 9 1

ASJC Scopus subject areas

  • 病理学および法医学
  • 分子生物学

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