Improving treatment of neurodevelopmental disorders: Recommendations based on preclinical studies

Judith R. Homberg, Evan J. Kyzar, Adam Michael Stewart, Michael Nguyen, Manoj K. Poudel, David J. Echevarria, Adam D. Collier, Siddharth Gaikwad, Viktor M. Klimenko, William Norton, Julian Pittman, Shun Nakamura, Mamiko Koshiba, Hideo Yamanouchi, Sergey A. Apryatin, Maria Luisa Scattoni, David M. Diamond, Jeremy F.P. Ullmann, Matthew O. Parker, Richard E. BrownCai Song, Allan V. Kalueff

研究成果: Review article査読

11 被引用数 (Scopus)

抄録

Introduction: Neurodevelopmental disorders (NDDs) are common and severely debilitating. Their chronic nature and reliance on both genetic and environmental factors makes studying NDDs and their treatment a challenging task.Areas covered: Herein, the authors discuss the neurobiological mechanisms of NDDs, and present recommendations on their translational research and therapy, outlined by the International Stress and Behavior Society. Various drugs currently prescribed to treat NDDs also represent a highly diverse group. Acting on various neurotransmitter and physiological systems, these drugs often lack specificity of action, and are commonly used to treat multiple other psychiatric conditions. There has also been relatively little progress in the development of novel medications to treat NDDs. Based on clinical, preclinical and translational models of NDDs, our recommendations cover a wide range of methodological approaches and conceptual strategies.Expert opinion: To improve pharmacotherapy and drug discovery for NDDs, we need a stronger emphasis on targeting multiple endophenotypes, a better dissection of genetic/epigenetic factors or "hidden heritability," and a careful consideration of potential developmental/trophic roles of brain neurotransmitters. The validity of animal NDD models can be improved through discovery of novel (behavioral, physiological and neuroimaging) biomarkers, applying proper environmental enrichment, widening the spectrum of model organisms, targeting developmental trajectories of NDD-related behaviors and comorbid conditions beyond traditional NDDs. While these recommendations cannot be addressed all in once, our increased understanding of NDD pathobiology may trigger innovative cross-disciplinary research expanding beyond traditional methods and concepts.

本文言語English
ページ(範囲)11-25
ページ数15
ジャーナルExpert Opinion on Drug Discovery
11
1
DOI
出版ステータスPublished - 2016 1月 2
外部発表はい

ASJC Scopus subject areas

  • 創薬

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