Improved preparation of l-[Methyl-11C]methionine by on-line [11C]methylation

Ken Ichiro Mizuno, Shigeki Yamazaki, Ren Iwata, Claudio Pascali, Tatsuo Ido

    研究成果: Article査読

    18 被引用数 (Scopus)

    抄録

    On-line [11C]methylation using [11C]methyl iodide has been successfully applied to the preparation of l-[methyl-11C]-methionine (11C-Met). [11C]Methyl iodide is first trapped in a short column that contains Porapak Q and l-homocysteine thiolactone coated on inert support. The column is then charged with NaOH dissolved in a mixture of ethanol and water to cause the [11C]methylation. The present method can provide practically pure 11C-Met in radiochemical yield of over 98%. The whole procedure including the sterilization of final product has been completely automated for routine PET use.

    本文言語English
    ページ(範囲)788-790
    ページ数3
    ジャーナルApplied Radiation and Isotopes
    44
    4
    DOI
    出版ステータスPublished - 1993 4

    ASJC Scopus subject areas

    • Radiation

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