Importance of the vasculature in cyst formation after spinal cord injury: Laboratory investigation

Gemma E. Rooney, Toshiki Endo, Syed Ameenuddin, Bingkun Chen, Sandeep Vaishya, Lou Ann Gross, Terry K. Schiefer, Bradford L. Currier, Robert J. Spinner, Michael J. Yaszemski, Anthony J. Windebank

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Object. Glial scar and cystic formation greatly contribute to the inhibition of axonal regeneration after spinal cord injury (SCI). Attempts to promote axonal regeneration are extremely challenging in this type of hostile environment. The objective of this study was to examine the surgical methods that may be used to assess the factors that influence the level of scar and cystic formation in SCI. Methods. In the first part of this study, a complete transection was performed at vertebral level T9-10 in adult female Sprague-Dawley rats. The dura mater was either left open (control group) or was closed using sutures or hyaluronic acid. In the second part of the study, complete or subpial transection was performed, with the same dural closure technique applied to both groups. Histological analysis of longitudinal sections of the spinal cord was performed, and the percentage of scar and cyst formation was determined. Results. Dural closure using sutures resulted in significantly less glial scar formation (p = 0.0248), while incorporation of the subpial transection surgical technique was then shown to significantly decrease cyst formation (p < 0.0001). Conclusions. In this study, the authors demonstrated the importance of the vasculature in cyst formation after spinal cord trauma and confirmed the importance of dural closure in reducing glial scar formation.

本文言語English
ページ(範囲)432-437
ページ数6
ジャーナルJournal of Neurosurgery: Spine
11
4
DOI
出版ステータスPublished - 2009 10
外部発表はい

ASJC Scopus subject areas

  • 外科
  • 神経学
  • 臨床神経学

フィンガープリント

「Importance of the vasculature in cyst formation after spinal cord injury: Laboratory investigation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル