TY - JOUR
T1 - Importance of nucleation in transformation of octacalcium phosphate to hydroxyapatite
AU - Ito, Natsuko
AU - Kamitakahara, Masanobu
AU - Yoshimura, Masahiro
AU - Ioku, Koji
N1 - Funding Information:
This work was partly supported by KAKENHI ( 11J04659 ) and the Nippon Sheet Glass Foundation for Materials Science and Engineering .
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/7/1
Y1 - 2014/7/1
N2 - Octacalcium phosphate (OCP) is regarded as an in vivo precursor of hydroxyapatite (HA). It is important to understand the mechanism of transformation of OCP to HA in order to reveal the mechanism of mineralization and help in the development of artificial bone-repairing materials. Herein, we have examined the behavior of OCP in a simulated body fluid (SBF) and pure water. The OCP particles immersed in the SBF at 37 °C did not transform to HA even after 720 h of immersion, though the particles showed crystal growth. In distilled water at 60 °C, the OCP particles transformed to HA but the unreactive period was observed. Although the immersed solution became supersaturated with HA within 12 h of immersion, the OCP was not transformed in the first 36 h of immersion. These results indicate that the nucleation of HA is the rate-determining step in the transformation of OCP to HA.
AB - Octacalcium phosphate (OCP) is regarded as an in vivo precursor of hydroxyapatite (HA). It is important to understand the mechanism of transformation of OCP to HA in order to reveal the mechanism of mineralization and help in the development of artificial bone-repairing materials. Herein, we have examined the behavior of OCP in a simulated body fluid (SBF) and pure water. The OCP particles immersed in the SBF at 37 °C did not transform to HA even after 720 h of immersion, though the particles showed crystal growth. In distilled water at 60 °C, the OCP particles transformed to HA but the unreactive period was observed. Although the immersed solution became supersaturated with HA within 12 h of immersion, the OCP was not transformed in the first 36 h of immersion. These results indicate that the nucleation of HA is the rate-determining step in the transformation of OCP to HA.
KW - Hydroxyapatite
KW - Octacalcium phosphate
KW - Transformation
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U2 - 10.1016/j.msec.2014.03.034
DO - 10.1016/j.msec.2014.03.034
M3 - Article
C2 - 24857473
AN - SCOPUS:84898492079
SN - 0928-4931
VL - 40
SP - 121
EP - 126
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -